Maggie L. Shaw. Blood Pressure Control and the Association with Diabetes Mellitus Incidence: Results from SPRINT Randomized Trial Christianne L. Roumie, Adriana M. Hung, Gregory B. Russell, Jan …
The importance of diabetes management in the primary care setting cannot be overstated. The initial SPRINT results reported about 5-and-a-half years ago were based on data collected through August 20, 2015, when the trial was prematurely stopped due to benefits in the intensive arm. ... pediatric diabetes centres, family health teams, and community … Objective To examine the effect of intensive versus standard blood pressure (BP) control on death or cardiovascular events in type 2 diabetes. Post hoc analyses have also indicated that intensive blood pressure control was associated with kidney injury in SPRINT and in the Action to Control Cardiovascular Risk in … In addition to primary sponsorship by the NHLBI, SPRINT is co-sponsored by the NIH’s National … The Action to Control Cardiovascular Risk in Diabetes Blood Pressure trial 3 (ACCORD BP) used the same SBP goals used in SPRINT to determine the value of intensive compared with that of stan-dard BP reduction in 4733 adults with diabetes mellitus, addi- PROGNOSISOF ACUTE MYOCARDIALINFARCTION I369 6. SPRINT Trial. The results from the overall SPRINT cohort differ from those of the ACCORD trial, which used a similar study protocol for intensive blood pressure lowering, except that only patients with type 2 diabetes were included in ACCORD but were excluded from SPRINT. The ACCORD trial enrolled participants with diabetes exclusively, whereas SPRINT excluded participants with diabetes; in addition, the sample size differed (4733 in ACCORD vs. … Hypertension is highly prevalent in the adult population in the United States, especially among persons older than 60 years of age, and affects approximately 1 billion adults worldwide.1,2 Among persons 50 years of age or older, isolated systolic hypertension is the most common form of hypertension,3,4 and systolic blood pressure becomes more i… STEP Trial Findings Build on SPRINT Results, With a Twist. A group of 2,500 participants with average age 80 and without diabetes were followed for 3 years.
Several important differences between these trials should be noted. Prior to the results of SPRINT (randomized trial of intensive versus standard blood‐pressure control), 3 a target systolic blood pressure (SBP) of 140 mmHg or less would … Objective To examine the effect of intensive versus …
STEP findings build on those from the SPRINT trial, … •SPRINT examined effects of more intensive antihypertensive therapy than currently recommended •Participants were US adults ≥50 years with hypertension and additional risk for VD •Rapid and sustained difference in SBP achieved between the two treatment arms •Trial stopped early, due to benefit, after median follow-up of 3.26 years The authors did a combined secondary analysis of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) blood pressure trial2 and the Systolic Blood … Hypertension –Not Too Low in Diabetes •↓ MACE < 140/90mm Hg •No clear netbenefit SBP < 130mm Hg •Individualize therapy ... 3.Diabetes with LDL 70-189mg/dL and 10 … Design Secondary analysis of the Action to Control Cardiovascular Risk in Diabetes Blood Pressure trial. — A systolic BP target of less than 120 mm Hg was associated with lower rates of death and CV events compared with a target of less than 140 mm Hg, according to results … SPRINT was a large randomized controlled trial with over 9,000 non-diabetic patients, funded by the NIH, to study the effect of intensive blood pressure control on cardiovascular health. The determination of probable dementia and MCI in SPRINT MIND relied on both screening and adjudication at follow-up visits and planned cognitive testing at years 2 and 4, and study closeout when it was more than 1 year after the year four evaluation. Action to Control Cardiovascular Mortality in Diabetes (ACCORD) Blood Pressure Trial •Compared treating to SBP goal of <120 vs <140 •No statistically significant benefit with treating to lower target when using ... SPRINT does support treating to a lower blood pressure goal in … Prior to the SPRINT trial, research had shown that treating high blood pressure helped decrease risk of CVD, but the optimum SBP goal was unknown.
Final results of the SPRINT trial published in T he New England Journal of Medicine in 2021, which were based on more than 3 years of follow-up, … Well, it is a population of Chinese patients: 90% are Han Chinese, so it validates the results of the SPRINT trial to China.
advised stricter blood pressure control due to the mortality benefits seen from the SPRINT trial (published in 2015 after JNC 8)3. SPRINT can be considered as the “twin” of ACCORD-BP trial, since it randomized 9361 hypertensives of increased cardiovascular burden but not diabetes or prior stroke, with … The Systolic Blood Pressure Intervention Trial (SPRINT) compared the effect of intensive versus standard systolic blood pressure targets on cardiovascular morbidity and … The landmark trial, led by Dr. Pamela Goodwin at Sinai Health and run by the Canadian Cancer Trials Group (CCTG) under the umbrella of the Breast International Group (BIG) … The Systolic Blood Pressure Intervention Trial (SPRINT) recently reported that participants assigned to an intensive SBP treatment target of less than 120 mm Hg vs the …
The SPRINT trial supports targeting a systolic blood pressure goal of <120 mm Hg ... and lower mortality compared to PCI with drug-eluting stents.The Bypass Angioplasty Revascularization … The major baseline characteristics for participants in ACCORD, and MCI in the SPRINT MIND trial has previously been described and relied on both screening and adjudica - tion at follow- up visits and planned cognitive testing at years 2 and 4, and study closeout when it was >1 year ... History of diabetes 137 (1.6%) 34 (1.2%) 49 (1.8%) 54 (1.9%) 0.088 The SPRINT trial (Systolic Blood Pressure Intervention Trial) found that a lower systolic target of 120 mmHg (as measured by automated office blood pressure) reduced … The Systolic Blood Pressure Intervention Trial (SPRINT) was designed to test the effect of more intensive BP control on cardiovascular (primary end point), renal, and cognitive outcomes in … SPRINT excluded participants with diabetes mellitus, prior stroke, and proteinuria > 1 g/d, all of which are linked with frailty and cognitive impairment. Diabetes) blood pressure trial used similar interventions but produced discordant results. Cardiovascular events and mortality were about 25% Methods—This analysis included 8,164 participants (mean age 67.9 years, 35.3% women, 31.2% blacks) with hypertension but no diabetes from the Systolic Blood Pressure Intervention … Trial (SPRINT) and the baseline characteristics of trial participants. This study is a sub-group analysis of the SPRINT (Systolic Blood Pressure Intervention Trial) research trial that was published last fall. The original SPRINT study enrolled 9361 adults aged 50+. This recently published analysis covers the results for the 2636 participants who were aged 75 or older. Prior to the SPRINT trial, research had shown that treating high blood pressure helped decrease risk of CVD, but the optimum SBP goal was unknown. PubMed • Full text • … For diabetes, the major study was called ACCORD (Action to Control Cardiovascular Risk in Diabetes) . https://www.acc.org/latest-in-cardiology/clinical-trials/2015/09/23/10/40/sprint Effects of Intensive Blood-Pressure Control in Type 2 Diabetes Mellitus. Basically, what we found in the SPRINT trial in the United … The NIH sponsored SPRINT trial was published in NEJM November 2015.
Participants were eligible for the analysis if they were in the standard glucose control arm of ACCORD-BP and also had the additional CVD risk factors required for SPRINT (Systolic Blood Pressure Intervention … SPRINT enrolled patients without diabetes.
CKD, with and without diabetes.
SPRINT excluded participants with diabetes mellitus, prior stroke, and proteinuria > 1 g/d, all of which are linked with frailty and cognitive impairment. SPRINT trial 1. Subcutaneous … It is the only large trial that examined CV events as the primary outcome and mortality as a secondary outcome … The Systolic Blood Pressure Intervention Trial (SPRINT) is a 2-arm, multicenter, randomized clinical trial designed to test whether a treatment program aimed at reducing systolic blood pressure (SBP) to a lower goal than currently recommended will reduce cardiovascular disease (CVD) risk. Follow-up tests discovered … SPRINT trial paints a different picture: older individuals with tight systolic blood pressure control <120 mmHg experienced less cardiovascular events and all-cause mortality compared to those with sBP<140 mmHg. Methods—SPRINT is a multi-center, randomized, controlled trial that compares two strategies for treating systolic blood pressure: one targets the standard target of <140 mm Hg, and the other targets a more intensive target of <120 mm Hg. Will more aggressive BP control reduce the risk of CV outcomes? Several clinical trials highlight the CV and renal benefits of treating hypertension in patients with DM, including notably the UK Prospective Diabetes Study (UKPDS) trial, the … We evaluated diabetes mellitus incidence in this randomized trial that compared intensive blood pressure strategy (systolic blood pressure <120 mm Hg) versus standard strategy (<140 mm Hg). D events in adults with stage 1 systolic hypertension with diabetes mellitus enrolled in Action to Control Cardiovascular Risk in Diabetes Blood Pressure trial (ACCORD BP) … 2020 Feb;75(2):331-338. doi: … High blood pressure is a major public health concern because it is a very common condition and a leading risk factor for other conditions, including heart attack, heart failure, stroke, chronic kidney disease, and Cognitive decline. SPRINT is the first large prospective randomized trial to show evidence of cardiovascular and mortality benefit for intensive lowering of systolic blood pressure (goal < … The SPRINT trial is the first randomized, controlled trial to convincingly show that a goal SBP of <120 mmHg measured by AOBP can be beneficial in patients with hypertension …
The SPRINT trial, reported earlier this week at the American Heart Association (AHA) ... And if you look at the 40 or so trials of blood-pressure reduction in diabetes, the take … Expert at Rittenhouse trial zeroes in on just a few minutes ... Navigator Looks Like A Secret Service Sprint. The New England Journal of Medicine. The SPRINT (Systolic Blood Pressure Intervention Trial) investigators now report in the Journal the results of a National Institutes of Health (NIH)–sponsored trial studying the impact on major cardiovascular events of a lower systolic blood-pressure target in adults with hypertension. It’s not too often that results of a clinical trial become so clear … Editor's Note: This is Part II (Cons) of a two-part Expert Analysis.Go to Part I (Pros). 2015. If you just want to know the essentials, skip down to the key takeaways at the end. This study is a sub-group analysis of the SPRINT (Systolic Blood Pressure Intervention Trial) research trial that was published last fall. The original SPRINT study enrolled 9361 adults aged 50+. He told attendees that …
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